specialist in genotoxicology or chemical hazard risk assessment, members will
be expected to:
- Contribute to discussions of the
Committee working alongside recognised experts who assess other aspects of the
detailed technical data on genotoxins under consideration (e.g., mode of
action/mechanism studies, traditional and novel toxicity testing strategies,
- Contribute to the Committee’s discussions
and to the consideration of detailed statements and conclusions from the
- Contribute to other discussions (such as
in working groups or to draft text within your specialism if the need
The Committee on Mutagenicity of Chemicals in Food, Consumer Products,
and the Environment (COM) advises government on the mutagenicity of chemicals
used in pesticides, pharmaceuticals, and other products.
COM provides independent advice to government departments and agencies
on the potential mutagenicity and genotoxicity of chemicals (whether they are
likely to cause mutation in cells), from natural products to new synthetic
chemicals used in pesticides or pharmaceuticals. It also advises on strategies and
research for genotoxicity testing.
The committee also advises on important general hazards (the inherent
property of the substance) or risk (the likelihood of mutagenetic or genotoxic
effects occurring after a given exposure) and gives recommendations for
COM is an advisory body and has no regulatory status. However, it may
provide advice to agencies that have a regulatory role.
Genetic toxicology: applicants must have experience in
the conduct and interpretation of in silico methods, and in vitro, and in vivo
tests. An interest in molecular
epidemiology would also be of value.
Carcinogenesis: applicants should be able to
demonstrate an interest in cancer risk assessment and in the mechanisms of
carcinogenesis both genotoxic and non –genotoxic mechanisms.
Toxicokinetics and metabolism: applicants should have expertise in
interpretation of data on the disposition, metabolism and Toxicokinetics of
chemicals and low dose effects especially in relation to genotoxicity testing.
Computational toxicology and Quantitative Structure
Activity Relationships (QSARs): applicants must have expertise in the
application of computational toxicology and QSARs and their application to
Epigenetics and trans-generational effects: applicants
with expertise in epigenetics with relevance to genotoxicity endpoints.
or developmental toxicology: applicants with expertise in developmental
toxicology and adverse reproductive effects of mutagenic and genotoxic chemicals.
Board meetings are usually held in London / Oxfordshire and Virtual. Future meetings are as per the below, with locations yet to be confirmed: